Vitamin B6 Levels

Your result, the one DNA position behind it, and what the research says.

7/10 confidence.

About Vitamin B6 Levels

Vitamin B6 helps run more than a hundred enzyme reactions, most of them in protein and neurotransmitter chemistry. What differs between people is less how much they absorb than how fast they clear it. This position sits inside an intron of NBPF3, a gene with no known role in B6 chemistry; its neighbor ALPL does, encoding the enzyme that strips the phosphate off the active form and begins clearing it. Which of them the signal really belongs to is not settled, but the association with blood B6 is among the strongest known for any vitamin.

Good to know: Blood level reflects clearance rate as much as intake. The gene this position sits in is not necessarily the one responsible for the effect. A lower steady-state level is not the same thing as being short of it.

Fun fact: Vitamin B6 is a cofactor in over a hundred separate enzyme reactions, more than almost any other vitamin.

Discovery: The link between this region and vitamin B6 blood levels was found in genome-wide studies of nutrient concentrations.

The Variant

The single variant behind this trait

Gene: NBPF3

Variant (rsID): rs4654748

Location: Chr 1:21,459,575

dbSNP rs4654748

The studies

Genome-wide association study of vitamin B6, vitamin B12, folate, and homocysteine blood concentrations (Tanaka T et al., American journal of human genetics, 2009)

Other lifestyle traits

Long-Chain Fat Burning: A change in one of the fat-burning enzymes inside mitochondria, linked to the level of a particular part-processed fat that shows up in blood.

Beta-Carotene Conversion: Two changes in the enzyme that converts beta-carotene from plants into vitamin A, which together cut its activity substantially.

Carotenoid Levels: A change in the master regulator of fat cells, linked to how much provitamin A carotenoid is stored in fat tissue.

Back to All Traits

Content updated September 2026.

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