Your result, the one DNA position behind it, and what the research says.
5/10 confidence.
Fats are burned inside mitochondria in a chain of steps, each handled by an enzyme tuned to a particular fat length. This variant swaps one building block of ACADL, and people who carry it have consistently higher blood levels of one part-processed fat, nonanoylcarnitine, across many separate studies. What that means is less settled than the gene's name suggests: in humans the ACADL protein is barely detectable in the tissues that burn fat, and a closely related enzyme does most of the long-chain work, so the raised marker is a reliable observation without an agreed mechanism behind it.
Good to know: Fats are burned by a chain of enzymes, each tuned to a different fat length. What this variant changes is a blood measurement, and the mechanism behind it is not settled. Many enzymes act in sequence, so a single slower step is rarely decisive.
Fun fact: Mitochondria strip fats two carbon atoms at a time, so a sixteen-carbon fat goes round the same cycle seven times before it is fully burned.
Discovery: The K333Q change was linked to blood acylcarnitine profiles in genome-wide studies of metabolites.
The single variant behind this trait
Gene: ACADL
Location: Chr 2:210,195,326
dbSNP rs2286963
Calcium Levels: A change on chromosome 3 linked to the level of calcium circulating in blood.
Content updated September 2026.
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