Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Zileuton is a 5-lipoxygenase inhibitor: it blocks the enzyme that makes leukotrienes, inflammatory signals that narrow the airways. It is used for long-term control of asthma in the US, as tablets taken several times a day or extended-release tablets. Liver tests are checked because it can raise liver enzymes. It is sold as Zyflo.
Zileuton is broken down by CYP1A2, CYP2C9 and CYP3A4 and by glucuronidation. The gene study listed, a genome-wide study of asthma response to leukotriene medicines, looked at PRORP (MRPP3). The evidence is weak, and there is no CPIC or DPWG guideline.
Every published finding on gene variants and Zileuton. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
PRORP rs12436663: Level 3. Efficacy: Asthma. 1.
Studies of how well it worked in people carrying a variant.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Advair (Corticosteroid + LABA)
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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