Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Fluticasone/salmeterol combines an inhaled corticosteroid, which calms airway inflammation, with salmeterol, a long-acting beta-2 agonist that keeps the airways open for about 12 hours. It is taken twice daily from one inhaler to control asthma and to reduce flare-ups in COPD. It is sold as Advair, Seretide and Wixela, among other names.
Both parts are broken down by CYP3A4, so strong CYP3A4 blockers such as ritonavir can raise fluticasone to levels with body-wide steroid effects. The gene studies listed looked at CHRM2, IL10, IL17A and ZNF432 for lung function response in asthma. The findings come from a few studies, and there is no CPIC or DPWG guideline.
Every published finding on gene variants and Advair. Upload your DNA file to see which of these rows apply to you.
Studies of how well it worked in people carrying a variant.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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