Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Vildagliptin is a DPP-4 inhibitor: it blocks the enzyme that breaks down incretins, gut hormones such as GLP-1 that tell the pancreas to release insulin after a meal. It is used for type 2 diabetes, alone or with metformin (Eucreas, Galvumet), in Europe, Asia and elsewhere but not in the US. It is sold as Galvus.
Vildagliptin is cleared mainly by hydrolysis, largely in the kidneys, and not by CYP enzymes. Studies have looked at genes of the incretin system (GLP1R, DPP4, GIPR) and diabetes genes such as WFS1, KCNJ11 and KCNQ1 for how much blood sugar fell. The findings come from single or a few studies, and there is no CPIC or DPWG guideline.
Every published finding on gene variants and Vildagliptin. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
GLP1R rs6923761: Level 3. Efficacy: Diabetes Mellitus, Type 2. 1.
Studies of how well it worked in people carrying a variant.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
DPP-4 Inhibitors (class) (DPP-4 Inhibitors)
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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