Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Sitagliptin is a DPP-4 inhibitor: it blocks the enzyme that breaks down incretins, gut hormones such as GLP-1 that tell the pancreas to release insulin after a meal. More incretin means more insulin when blood sugar is high and less glucagon. It is used for type 2 diabetes, alone or with metformin (Janumet). It is sold as Januvia.
Sitagliptin is cleared mostly unchanged by the kidneys, so drug-processing genes play little part. Studies have looked at genes of the incretin system, such as GLP1R (the GLP-1 receptor), DPP4 and GIPR, and at diabetes genes such as KCNJ11, KCNQ1 and WFS1, for how much blood sugar fell. The findings come from single or a few studies, and there is no CPIC or DPWG guideline.
Every published finding on gene variants and Sitagliptin. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
GLP1R rs6923761: Level 3. Efficacy: Diabetes Mellitus, Type 2. 1.
Studies of how well it worked in people carrying a variant.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
DPP-4 Inhibitors (class) (DPP-4 Inhibitors)
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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