Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Tenofovir is an antiviral of the NRTI group (nucleotide reverse transcriptase inhibitors): it is built into viral DNA as it is copied and stops the chain from growing. It is used for HIV, in combination with other medicines and to prevent infection (PrEP), and for chronic hepatitis B. It is sold as Viread (tenofovir disoproxil, TDF) and in newer form as tenofovir alafenamide (TAF, Vemlidy), and in many combination tablets.
Tenofovir is not broken down by liver enzymes; the kidneys clear it, pulling it into kidney cells with SLC22A6 (OAT1) and pumping it out with ABCC4 and ABCC2. Studies have linked variants in these transporters to tenofovir levels inside cells and to kidney side effects. The findings come from single or a few studies, and there is no CPIC or DPWG guideline.
Every published finding on gene variants and Tenofovir. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
ABCC2 rs717620: Level 3. Toxicity: HIV infectious disease. 5.
ABCC4 rs3742106: Level 3. Metabolism/PK: HIV infectious disease. 3.
ABCC4 rs1059751: Level 3. Toxicity: HIV infectious disease. 2.
ABCC2 rs17222723: Level 3. Toxicity: HIV infectious disease. 2.
Studies of how quickly the body processes this medication.
Studies of how well it worked in people carrying a variant.
Studies of side effects in people carrying a variant.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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