Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Nucleoside and nucleotide reverse transcriptase inhibitors (NRTIs) are a class of antivirals that are built into viral DNA as it is copied and stop the chain from growing. The class includes tenofovir, emtricitabine, lamivudine, abacavir and zidovudine; most HIV treatment combinations contain two of them, and some also treat hepatitis B. This page collects studies on NRTIs as a group.
PharmGKB lists a single low-rated finding for the class as a group. The strongest gene finding for an NRTI is HLA-B*57:01 and abacavir hypersensitivity, covered by CPIC and DPWG guidelines on the abacavir page. Most NRTIs are cleared by the kidneys and activated inside cells, so the common liver-enzyme genes matter little.
Every published finding on gene variants and NRTIs. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
rs2853826: Level 3. Toxicity: HIV infectious disease. 1.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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