Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Lamivudine (3TC) is a nucleoside reverse transcriptase inhibitor: it is built into viral DNA as it is copied and stops the chain from growing. It is one of the most used HIV medicines, part of many combination tablets such as Triumeq and Dovato, and at a lower dose treats chronic hepatitis B. It is sold as Epivir, among other names.
Lamivudine is cleared mostly unchanged by the kidneys, with the help of the transporters SLC22A2 (OCT2) and MATEs. Gene studies listing it were mostly done in people on combination HIV treatment and looked at ABCB1, ABCC1, CYP2B6 and HLA-B, findings that largely concern the other medicines. There is no CPIC or DPWG guideline.
Every published finding on gene variants and Lamivudine. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
ABCC1 rs212091: Level 3. Efficacy: HIV infectious disease. 1.
Studies of how quickly the body processes this medication.
Studies of how well it worked in people carrying a variant.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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