Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Telbivudine was a nucleoside analogue antiviral for chronic hepatitis B that blocked the virus's DNA polymerase. It was discontinued around 2016 because resistance developed often and it could cause muscle and nerve side effects; entecavir and tenofovir are used instead. It was sold as Tyzeka and Sebivo.
Telbivudine is activated inside cells by kinases and cleared unchanged by the kidneys. The gene studies listed looked at TK2 and RRM2B, mitochondrial genes, in relation to its muscle side effects. The findings come from a few studies, and there is no CPIC or DPWG guideline.
Every published finding on gene variants and Telbivudine. Upload your DNA file to see which of these rows apply to you.
Studies of how quickly the body processes this medication.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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