Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Siponimod is an immunomodulator for multiple sclerosis. It binds sphingosine-1-phosphate (S1P) receptors on white blood cells and keeps many of them inside the lymph nodes, so fewer reach the brain and spinal cord. It is used for relapsing forms of multiple sclerosis, including active secondary progressive MS. It is sold as Mayzent.
Siponimod is broken down mainly by the liver enzyme CYP2C9, and it is one of the few medicines whose US label asks for a person's CYP2C9 genotype before treatment starts. People with two copies of the reduced-function *3 version have several times the usual exposure, and those with one copy clearly more than average. DPWG has published a guideline on CYP2C9 and siponimod, and the US FDA lists the pair.
Clinical guidelines that name a gene for Mayzent. They sort people into groups by the gene copies they carry.
US FDA: CYP2C9. *2/*3 · *1/*2 · *3/*3 · *2/*2 · *1/*1 · *1/*3.
Every published finding on gene variants and Mayzent. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
CYP2C9 CYP2C9*1, CYP2C9*2, CYP2C9*3: Level 1A · replicated. Metabolism/PK. 2.
Studies of how quickly the body processes this medication.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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