Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Risedronate is a bisphosphonate: it binds to bone and slows the osteoclasts that break bone down, so bone density is preserved and fractures become less likely. It is taken as a daily, weekly or monthly tablet for osteoporosis after the menopause, in men, and with long-term steroid use, and for Paget's disease of bone. It is sold as Actonel and Atelvia, among other names.
Risedronate is not broken down; what bone does not take up is cleared by the kidneys. The few gene studies listing it looked at IL1B and at LRP5, a gene important for bone formation, for how much bone density improved. The findings come from a few studies, and there is no CPIC or DPWG guideline.
Every published finding on gene variants and Risedronate. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
IL1B rs16944: Level 3. Efficacy: Osteitis Deformans. 1.
Studies that do not fall into the groups above.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Bisphosphonates (class) (Bisphosphonates)
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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