Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Etidronic acid (etidronate) was the first bisphosphonate used in medicine. It binds to bone and slows bone breakdown, but at higher doses also impairs bone mineralisation. It has been used for Paget's disease of bone, osteoporosis (in cycles) and to prevent bone formation in soft tissues after hip surgery or spinal injury; newer bisphosphonates have largely replaced it. It is sold as Didronel.
Etidronate is not broken down; what bone does not take up is cleared by the kidneys. The gene studies listed looked at IL1B and COL1A1 for bone density response. The findings come from a few studies, and there is no CPIC or DPWG guideline.
Every published finding on gene variants and Etidronic Acid. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
IL1B rs16944: Level 3. Efficacy: Osteitis Deformans. 1.
Studies of how well it worked in people carrying a variant.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Bisphosphonates (class) (Bisphosphonates)
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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