Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Clodronate is a first-generation bisphosphonate without a nitrogen group: it binds to bone and is taken up by osteoclasts, which it disables. It is used in Europe and elsewhere for bone damage and high calcium caused by cancer, especially multiple myeloma and breast cancer that has spread to bone; it is not approved in the US. It is sold as Bonefos and Loron.
Clodronate is not broken down; what bone does not take up is cleared unchanged by the kidneys. The few gene studies listing it looked at VDR, the vitamin D receptor, and IL1B for bone response. The findings come from a few studies, and there is no CPIC or DPWG guideline.
Every published finding on gene variants and Clodronate. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
VDR rs731236: Level 3. Efficacy: Osteitis Deformans. 1.
IL1B rs16944: Level 3. Efficacy: Osteitis Deformans. 1.
VDR rs1544410: Level 3. Efficacy. 1.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Bisphosphonates (class) (Bisphosphonates)
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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