Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Bisphosphonates are a class of medicines that bind to bone and slow down osteoclasts, the cells that break bone down, so bone density is preserved. The class includes alendronate, risedronate, ibandronate and zoledronic acid. They are used for osteoporosis, Paget's disease of bone and bone problems caused by cancer. This page collects studies on bisphosphonates as a group.
Bisphosphonates are not broken down in the body; they are taken up into bone or cleared by the kidneys. Studies have looked at FDPS, the gene for the enzyme the stronger bisphosphonates block, for how much bone density improved, and genome-wide studies have searched for genes linked to rare jaw bone damage (osteonecrosis), flagging SFRP5, RBMS3 and others. The findings come from single or a few studies, and there is no CPIC or DPWG guideline.
Every published finding on gene variants and Bisphosphonates. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
FDPS rs2297480: Level 3. Efficacy: Osteoporosis, Osteoporosis, Postmenopausal. 2.
FDPS rs11264359: Level 3. Efficacy: Coronary Disease, Osteoporosis. 2.
IL1B rs16944: Level 3. Efficacy: Osteitis Deformans. 1.
SFRP5 rs11189381: Level 3. Toxicity: Osteonecrosis. 1.
Studies of how well it worked in people carrying a variant.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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