Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Proton pump inhibitors (PPIs) are a class of medicines that switch off the pumps in the stomach lining that release acid. The class includes omeprazole, esomeprazole, lansoprazole, pantoprazole and rabeprazole, among the most used medicines in the world, for heartburn, acid reflux, ulcers, Helicobacter pylori treatment and stomach protection. This page collects studies on PPIs as a group.
The key gene for most PPIs is CYP2C19, which breaks them down: poor metabolizers keep them longer and have less stomach acid, and people with the fast *17 version clear them faster. CPIC and DPWG have published guidelines on CYP2C19 for omeprazole, lansoprazole, pantoprazole and dexlansoprazole, on their own pages. The studies listed for the class also looked at ABCB1 and STAT6.
Every published finding on gene variants and PPIs. Upload your DNA file to see which of these rows apply to you.
Studies of how well it worked in people carrying a variant.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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