Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Esomeprazole is a proton pump inhibitor (PPI), the S-form of omeprazole, which the body clears more slowly than the mixture. It switches off the pumps in the stomach lining that release acid, and is used for heartburn and acid reflux, ulcers, Helicobacter pylori treatment and to protect the stomach during NSAID use. It is sold as Nexium, among other names.
Esomeprazole is broken down by CYP2C19 and CYP3A4. It depends on CYP2C19 somewhat less than omeprazole, but poor metabolizers still have higher levels, which the US FDA lists as an effect on drug levels, and studies have compared healing and Helicobacter cure by CYP2C19 type. CPIC's PPI guideline did not include esomeprazole.
Clinical guidelines that name a gene for Esomeprazole. They sort people into groups by the gene copies they carry.
Every published finding on gene variants and Esomeprazole. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
CYP2C19 CYP2C19*1, CYP2C19*2, CYP2C19*3: Level 3. Efficacy: Gastroesophageal Reflux, Helicobacter Infections. 13.
CYP2C19 CYP2C19*1, CYP2C19*2, CYP2C19*3: Level 3. Metabolism/PK. 3.
STAT6 rs1059513: Level 3. Efficacy: eosinophilic esophagitis. 1.
Studies of how quickly the body processes this medication.
Studies of how well it worked in people carrying a variant.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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