Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Platinum medicines are a class of chemotherapy drugs built around a platinum atom: they bind DNA and cross-link its strands, so cancer cells cannot copy it and die. The class includes cisplatin, carboplatin and oxaliplatin, used for testicular, ovarian, lung, bladder, bowel, head and neck and many other cancers. This page collects studies on platinum medicines as a group.
Studies of the class as a whole have looked at DNA repair genes (ERCC1, ERCC2, ERCC5), which help cancer cells mend platinum damage, and at the detoxifying enzyme GSTP1, for response and side effects, and at transporter and water-channel genes such as AQP2 and AQP9. The findings come from single or a few studies and often disagree, and there is no CPIC or DPWG guideline.
Every published finding on gene variants and Platinum. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
ERCC2;KLC3 rs13181: Level 3. Efficacy: Colorectal Neoplasms, Neoplasm of esophagus, Osteosarcoma, Ovarian Neoplasms, Pancreatic Neoplasms. 9.
ERCC1 rs11615: Level 3. Toxicity: Neoplasms. 6.
GSTP1 rs1695: Level 3. Efficacy: Colorectal Neoplasms. 1.
ERCC5 rs17655: Level 3. Efficacy: Ovarian Neoplasms. 1.
Studies of how well it worked in people carrying a variant.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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