Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Carboplatin is a platinum chemotherapy medicine, a gentler relative of cisplatin: it cross-links the strands of DNA so cancer cells cannot copy it. It is used for ovarian and lung cancers and many others, often combined with paclitaxel. It causes less kidney damage and hearing loss than cisplatin, but lowers blood counts more. It is sold as Paraplatin, among other names.
Carboplatin is cleared unchanged by the kidneys, so its level depends mostly on kidney function rather than on genes. Studies have looked at DNA repair genes (such as XRCC1), growth-signal genes (AKT1, ERBB3, VEGFA) and transporters for response and side effects. The findings come from single or a few studies, and there is no CPIC or DPWG guideline.
Every published finding on gene variants and Carboplatin. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
ERCC1 rs11615: Level 3. Toxicity: Neoplasms. 6.
MTHFR rs1801131: Level 3. Efficacy: Neoplasms. 4.
MTR rs1805087: Level 3. Efficacy, Toxicity: Neoplasms. 3.
SLCO1B3 rs4149117: Level 3. Toxicity: Lung Neoplasms. 2.
Studies of how well it worked in people carrying a variant.
Studies of side effects in people carrying a variant.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Platinum (class) (Platinum Agents)
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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