Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Cisplatin is a platinum chemotherapy medicine: it binds to DNA and cross-links its strands, so cancer cells cannot copy it and die. It is used for testicular, ovarian, bladder, lung, head and neck, and cervical cancers, among others. Known side effects include kidney damage and hearing loss. It is sold as Platinol, among other names.
Many studies have looked for genes that change how well cisplatin works or how likely its side effects are, but no gene has made it into a CPIC or DPWG guideline. The most studied are DNA repair genes such as ERCC1 and ERCC2, the detoxifying enzyme GSTP1, and, for hearing loss in children, TPMT, COMT and ACYP2. The findings come from one or a few studies each and often disagree.
Every published finding on gene variants and Cisplatin. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
TPMT rs12201199: Level 3. Toxicity: Neoplasms. 9.
ERCC2;KLC3 rs13181: Level 3. Efficacy: Colorectal Neoplasms, Neoplasm of esophagus, Osteosarcoma, Ovarian Neoplasms, Pancreatic Neoplasms. 9.
TPMT rs1142345: Level 3. Toxicity: Drug Toxicity, Neoplasms, Ototoxicity. 8.
COMT rs9332377: Level 3. Toxicity: Drug Toxicity, Neoplasms, Ototoxicity. 8.
Studies of how well it worked in people carrying a variant.
Studies of side effects in people carrying a variant.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Platinum (class) (Platinum Agents)
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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