Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Oxaliplatin is a third-generation platinum chemotherapy medicine that cross-links DNA. It is a mainstay of treatment for bowel cancer, both after surgery and for advanced disease, usually in FOLFOX, CAPOX or FOLFIRINOX, and is also used for stomach and pancreatic cancers. Nerve damage, including sensitivity to cold, is its typical side effect. It is sold as Eloxatin, among other names.
Oxaliplatin breaks down in the blood without needing liver enzymes. Studies have looked at DNA repair genes (ERCC1, ERCC2), the detoxifying enzyme GSTP1, and VEGF pathway genes for response, and at genes linked to its nerve damage. Many studies list folate and fluorouracil genes (MTHFR, TYMS) because oxaliplatin is given together with fluorouracil. The findings come from single or a few studies, and there is no CPIC or DPWG guideline.
Every published finding on gene variants and Oxaliplatin. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
MTHFR rs1801131: Level 3. Toxicity: Neoplasms. 11.
ERCC2;KLC3 rs13181: Level 3. Efficacy: Colorectal Neoplasms, Neoplasm of esophagus, Osteosarcoma, Ovarian Neoplasms, Pancreatic Neoplasms. 9.
ERCC1 rs11615: Level 3. Toxicity: Neoplasms. 6.
GSTP1 rs1695: Level 3. Toxicity: Colorectal Neoplasms, Gastrointestinal Neoplasms, Non-Small Cell Lung Carcinoma, Ovarian Neoplasms. 6.
Studies of how well it worked in people carrying a variant.
Studies of side effects in people carrying a variant.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Platinum (class) (Platinum Agents)
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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