Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Pitrakinra was an experimental medicine for asthma, a modified form of interleukin-4 that blocks the IL-4 receptor alpha chain and so both IL-4 and IL-13 signalling, key drivers of allergic airway inflammation. It was tested as an inhaled treatment in clinical trials but was not approved; dupilumab, an antibody acting on the same receptor, later reached the market.
The gene studies on pitrakinra came from one clinical trial, which found that people with certain variants in IL4R, the gene for its target receptor, had fewer asthma flare-ups on it. This was an early example of matching an asthma treatment to a patient's genes, but the medicine was not developed further. There is no CPIC or DPWG guideline.
Every published finding on gene variants and Pitrakinra. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
IL4R rs3024530: Level 3. Efficacy: Asthma. 1.
IL4R rs1110470: Level 3. Efficacy: Asthma. 1.
IL4R rs2239347: Level 3. Efficacy: Asthma. 1.
IL4R rs1805010: Level 3. Efficacy: Asthma. 1.
Studies of how well it worked in people carrying a variant.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Advair (Corticosteroid + LABA)
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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