Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Pantoprazole is a proton pump inhibitor (PPI): it switches off the pumps in the stomach lining that release acid. It is used for heartburn and acid reflux, for stomach and duodenal ulcers, as part of the treatment that clears Helicobacter pylori, and to protect the stomach during some other treatments. It is sold as Protonix, among other names.
Pantoprazole, like most PPIs, is broken down mainly by the liver enzyme CYP2C19. People with low-function copies (intermediate and poor metabolizers) keep it in the blood longer, so acid is held down more; people with the fast *17 version clear it quickly, and studies link that to lower healing and Helicobacter cure rates. CPIC and DPWG have published guidelines on CYP2C19 and pantoprazole, and the US drug label discusses poor metabolizers. A few other genes have been studied, with weaker evidence.
Clinical guidelines that name a gene for Pantoprazole. They sort people into groups by the gene copies they carry.
US FDA: CYP2C19. Likely Poor Metabolizer · Poor Metabolizer. 2018.
Every published finding on gene variants and Pantoprazole. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
CYP2C19 CYP2C19*1, CYP2C19*2, CYP2C19*3, CYP2C19*17: Level 1A · replicated. Metabolism/PK. 7.
CYP2C19 CYP2C19*1, CYP2C19*2, CYP2C19*3: Level 1A · replicated. Efficacy: Helicobacter Infections, Ulcer. 6.
ABCB1 rs1045642: Level 4. Efficacy: Helicobacter Infections. 4.
Studies of how quickly the body processes this medication.
Studies of how well it worked in people carrying a variant.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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