Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Palonosetron is a long-acting anti-sickness medicine of the 5-HT3 antagonist group: it blocks serotonin receptors in the gut and the brain's vomiting centre, and lasts several days. It is given before chemotherapy to prevent both early and delayed nausea and vomiting, and to prevent sickness after surgery. It is sold as Aloxi, and with netupitant as Akynzeo.
Palonosetron is broken down partly by CYP2D6 but is much less affected by it than ondansetron or tropisetron, and the CPIC guideline on CYP2D6 and the 5-HT3 antagonists does not cover it. Studies have looked at the transporters ABCB1 and ABCG2, the serotonin receptor genes HTR3B, HTR3C and HTR3D, and TACR1 for how well it prevented vomiting. The findings come from single or a few studies.
Every published finding on gene variants and Palonosetron. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
ERCC1 rs3212986: Level 3. Efficacy: Nausea, Neoplasms, Vomiting. 1.
Studies of how well it worked in people carrying a variant.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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