Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Granisetron is an anti-sickness medicine of the 5-HT3 antagonist group: it blocks serotonin receptors in the gut and the brain's vomiting centre. It is used to prevent nausea and vomiting caused by chemotherapy, radiotherapy and surgery, as tablets, injection or a skin patch. It is sold as Kytril and Sancuso, among other names.
Unlike ondansetron and tropisetron, granisetron is broken down mainly by CYP3A4 rather than CYP2D6, so the CPIC guideline on CYP2D6 and the 5-HT3 antagonists does not apply to it. Studies have looked at the transporters ABCB1 and ABCG2, the serotonin receptor genes HTR3B and HTR3C, and the substance P receptor TACR1 for how well it prevented vomiting. The findings come from single or a few studies.
Every published finding on gene variants and Granisetron. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
ABCB1 rs1045642: Level 3. Efficacy: Neoplasms. 2.
NOS1AP rs10494366: Level 3. Toxicity. 1.
ERCC1 rs3212986: Level 3. Efficacy: Nausea, Neoplasms, Vomiting. 1.
CYP1A1 CYP1A1*1, CYP1A1*2A: Level 3. Metabolism/PK. 1.
Studies of how quickly the body processes this medication.
Studies of how well it worked in people carrying a variant.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
ReadYourDNA provides educational interpretation of DNA data you already have. It is not diagnostic, not a substitute for professional medical advice, diagnosis, or treatment, and is not intended to diagnose, treat, cure, or prevent any disease. Talk to a clinician before acting on any result.
Raw DNA Data Reports for 23andMe & AncestryDNA · About ReadYourDNA · FAQ · Methodology & Science · Pricing · Support and complaints · Legal & Contact · Health Traits · Pharmacogenomics · Carrier Status · Variant Explorer · The Human Karyotype · Privacy Policy · Terms of Service · Accessibility · Consumer Health Data Privacy · Your Privacy Choices · Editorial Standards · Your Data, Checkable · Sample Report · ReadYourDNA and Promethease compared · What is inside a 23andMe raw data file · What is inside an AncestryDNA raw data file · What a chatbot can and cannot do with your raw DNA file · Where a raw DNA file can still be uploaded in 2026
Written, maintained and operated by Martin Pechhacker, sole proprietor, Vienna, Austria. Trade register GISA 40064420. support@readyourdna.com