Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Oxazepam is a short-to-intermediate acting benzodiazepine, itself an active breakdown product of diazepam, that strengthens the calming effect of GABA. It is used for anxiety and alcohol withdrawal, and is often chosen for older people and those with liver disease because of its simple clearance. It is sold as Serax and Seresta, among other names.
Oxazepam is not broken down by CYP enzymes; it is joined to glucuronic acid, mainly by UGT2B15, and cleared by the kidneys. Studies linked the UGT2B15*2 variant to slower clearance of the S-form of oxazepam. The findings come from a few studies, and there is no CPIC or DPWG guideline.
Every published finding on gene variants and Oxazepam. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
UGT2B15 rs1902023: Level 3. Metabolism/PK. 3.
rs1976391: Level 3. Metabolism/PK. 1.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Benzodiazepines (class) (Benzodiazepines)
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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