Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Lorazepam is a benzodiazepine that strengthens the calming effect of GABA in the brain. It is used for short-term relief of severe anxiety, before procedures, to stop prolonged seizures, and for alcohol withdrawal and agitation. It is sold as Ativan, among other names.
Unlike many benzodiazepines, lorazepam is not broken down by CYP enzymes; it is joined to glucuronic acid by UGT2B15 and UGT2B7 and cleared by the kidneys. A study linked the UGT2B15*2 variant to slower clearance, and others looked at UGT2B7. The findings come from a few studies, and there is no CPIC or DPWG guideline.
Every published finding on gene variants and Lorazepam. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
UGT2B15 rs1902023: Level 3. Metabolism/PK. 1.
Studies of how well it worked in people carrying a variant.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Benzodiazepines (class) (Benzodiazepines)
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
ReadYourDNA provides educational interpretation of DNA data you already have. It is not diagnostic, not a substitute for professional medical advice, diagnosis, or treatment, and is not intended to diagnose, treat, cure, or prevent any disease. Talk to a clinician before acting on any result.
Raw DNA Data Reports for 23andMe & AncestryDNA · About ReadYourDNA · FAQ · Methodology & Science · Pricing · Support and complaints · Legal & Contact · Health Traits · Pharmacogenomics · Carrier Status · Variant Explorer · The Human Karyotype · Privacy Policy · Terms of Service · Accessibility · Consumer Health Data Privacy · Your Privacy Choices · Editorial Standards · Your Data, Checkable · Sample Report · ReadYourDNA and Promethease compared · What is inside a 23andMe raw data file · What is inside an AncestryDNA raw data file · What a chatbot can and cannot do with your raw DNA file · Where a raw DNA file can still be uploaded in 2026
Written, maintained and operated by Martin Pechhacker, sole proprietor, Vienna, Austria. Trade register GISA 40064420. support@readyourdna.com