Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Methacholine is a substance related to acetylcholine that narrows the airways by acting on muscarinic receptors. It is not a treatment: it is breathed in during a lung function test (bronchial challenge) to see how sensitive the airways are, which helps confirm or rule out asthma. It is sold as Provocholine.
The few gene studies on methacholine used the challenge test as a measure of airway sensitivity and looked at ADRB2, the beta-2 receptor that asthma relievers act on, and RUNX1. The findings come from a few studies, and there is no CPIC or DPWG guideline.
Every published finding on gene variants and Methacholine. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
ADRB2 rs1042713: Level 3. Efficacy: Asthma. 1.
Studies of how well it worked in people carrying a variant.
Studies that do not fall into the groups above.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Advair (Corticosteroid + LABA)
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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