Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Mepolizumab is a biologic medicine, a monoclonal antibody that neutralises interleukin-5, the main signal that recruits and sustains eosinophils, a type of white blood cell. Injected monthly, it is used for severe eosinophilic asthma, chronic rhinosinusitis with nasal polyps, eosinophilic granulomatosis with polyangiitis and hypereosinophilic syndrome. It is sold as Nucala.
As an antibody, mepolizumab is not broken down by drug-processing enzymes. The gene studies listed looked at ADRB2 and HLA-DQA1 for response in asthma. The findings come from a few studies, and there is no CPIC or DPWG guideline. Whether it is used depends mostly on the blood eosinophil count, not on genes.
Every published finding on gene variants and Mepolizumab. Upload your DNA file to see which of these rows apply to you.
Studies of how well it worked in people carrying a variant.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Advair (Corticosteroid + LABA)
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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