Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Clobazam is a benzodiazepine of the 1,5-benzodiazepine type that strengthens the calming effect of GABA with somewhat less sedation than classic benzodiazepines. It is used mainly as an add-on for seizures in Lennox-Gastaut syndrome and other epilepsies, and in some countries for anxiety. It is sold as Onfi, Sympazan and Frisium.
Clobazam is turned by CYP3A4 into N-desmethylclobazam, which is also active and reaches higher levels than clobazam itself; CYP2C19 then breaks that down. In CYP2C19 poor metabolizers, N-desmethylclobazam builds up to several times the usual level, which the US label addresses and the US FDA lists. There is no CPIC or DPWG guideline; the studies on this page mostly concern CYP2C19.
Clinical guidelines that name a gene for Clobazam. They sort people into groups by the gene copies they carry.
US FDA: CYP2C19. Likely Poor Metabolizer · Poor Metabolizer.
Every published finding on gene variants and Clobazam. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
CYP2C19 CYP2C19*1, CYP2C19*2, CYP2C19*3: Level 3. Metabolism/PK: Epilepsy. 8.
CYP2C19 CYP2C19*1, CYP2C19*2, CYP2C19*3: Level 3. Dosage: Epilepsy. 1.
CYP2C19 CYP2C19*1, CYP2C19*2, CYP2C19*3: Level 3. Efficacy: Epilepsy. 1.
SCN1A rs2298771: Level 4. Efficacy: Epilepsy. 4.
Studies of how quickly the body processes this medication.
Studies of how well it worked in people carrying a variant.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Benzodiazepines (class) (Benzodiazepines)
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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