Latanoprost (Xalatan)

Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.

About Latanoprost

What it is

Latanoprost is a prostaglandin analogue eye drop: it activates prostaglandin F receptors in the eye and helps fluid drain out through a second route, lowering the pressure inside the eye. It is used once a day for open-angle glaucoma and raised eye pressure. It can darken the iris and lengthen eyelashes. It is sold as Xalatan, among other names.

How genes come into it

Latanoprost is a prodrug activated by esterases in the cornea. Studies, many from Japan, have looked at PTGFR, the gene for the receptor it acts on, and at PTGS1 and the transporter ABCC4, for how much eye pressure fell. The findings come from a few studies, and there is no CPIC or DPWG guideline.

What research found

Every published finding on gene variants and Latanoprost. Upload your DNA file to see which of these rows apply to you.

Rated evidence (4 rated variants)

PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.

PTGFR rs3753380: Level 3. Efficacy: Open-angle glaucoma. 2.

PTGFR rs3766355: Level 3. Efficacy: Open-angle glaucoma. 2.

PTGS1 rs10306114: Level 3. Efficacy: Open-angle glaucoma. 1.

ABCC4 rs11568658: Level 3. Efficacy: Open-angle glaucoma. 1.

Response (8 findings)

Studies of how well it worked in people carrying a variant.

ABCC4 rs11568658: Genotype AC is associated with decreased response to latanoprost in people with Glaucoma, Open-Angle as compared to genotype CC.

PTGFR rs3753380: Genotype CC is associated with increased response to latanoprost as compared to genotypes CT + TT.

PTGFR rs3766355: Genotype CC is associated with increased response to latanoprost in people with Glaucoma or Ocular Hypertension as compared to genotypes AA + AC.

ABCC4 rs11568668: Genotype TT is not associated with response to latanoprost in people with Glaucoma, Open-Angle as compared to genotypes CC + CT.

Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.

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Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.

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Content updated September 2026.

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