Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Lansoprazole is a proton pump inhibitor (PPI): it switches off the pumps in the stomach lining that release acid. It is used for heartburn and acid reflux, for stomach and duodenal ulcers, and as part of the treatment that clears Helicobacter pylori. It is sold as Prevacid, among other names.
Lansoprazole is broken down mainly by the liver enzyme CYP2C19. Poor and intermediate metabolizers keep it in the blood longer, so stomach acid stays lower, and studies link this to higher Helicobacter cure rates; people with the fast *17 version clear it more quickly. CPIC and DPWG have published guidelines on CYP2C19 and lansoprazole, and the US FDA lists an effect on drug levels. A few other genes have been studied, with weaker evidence.
Clinical guidelines that name a gene for Lansoprazole. They sort people into groups by the gene copies they carry.
Every published finding on gene variants and Lansoprazole. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
CYP2C19 CYP2C19*1, CYP2C19*2, CYP2C19*3: Level 1A · replicated. Efficacy: Gastroesophageal Reflux, Helicobacter Infections. 22.
CYP2C19 CYP2C19*1, CYP2C19*2, CYP2C19*3, CYP2C19*8, CYP2C19*9, CYP2C19*17: Level 1A · replicated. Metabolism/PK: Gastroesophageal Reflux. 9.
IL1B rs16944: Level 3. Efficacy: Helicobacter Infections. 3.
ABCB1 rs1045642: Level 3. Metabolism/PK: Gastroesophageal Reflux, Transplantation. 1.
Studies of how quickly the body processes this medication.
Studies of how well it worked in people carrying a variant.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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