Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Statins (HMG-CoA reductase inhibitors) are a class of medicines that block the liver enzyme that makes cholesterol, so the liver takes more LDL cholesterol out of the blood. The class includes atorvastatin, rosuvastatin, simvastatin, pravastatin, pitavastatin, fluvastatin and lovastatin. They are among the most prescribed medicines in the world, used to lower cholesterol and the chance of heart attack and stroke. This page collects studies on statins as a group.
The strongest gene for the class is SLCO1B1, which makes the transporter that carries statins into the liver: its common variant rs4149056 raises statin levels in the blood and the chance of muscle symptoms, most of all with simvastatin. CPIC has published a guideline on SLCO1B1 (and for some statins ABCG2 and CYP2C9), covered on the pages of the individual statins. Studies have also looked at HMGCR, LPA, KIF6 and CETP for how much cholesterol or heart risk fell.
Every published finding on gene variants and Statins. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
SLCO1B1 rs4149056: Level 2A · replicated. Toxicity: statin-related myopathy. 9.
HMGCR rs17238540: Level 3. Efficacy. 6.
SLCO1B1 rs4149056: Level 3. Efficacy: Cardiovascular Disease, Hyperlipidemias. 5.
SLCO1B1 rs2306283: Level 3. Toxicity: Coronary Artery Disease, Diabetes Mellitus, Hypercholesterolemia. 4.
Studies of how well it worked in people carrying a variant.
Studies of side effects in people carrying a variant.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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