Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Fluvastatin is a statin: it blocks HMG-CoA reductase, the liver enzyme that makes cholesterol, so the liver takes more LDL cholesterol out of the blood. It is a milder statin used to lower cholesterol and, after a coronary procedure, to reduce further heart events. It is sold as Lescol, among other names.
Unlike most statins, fluvastatin is broken down mainly by CYP2C9, so two genes shape its blood level: CYP2C9, whose reduced-function versions *2 and *3 slow its clearance, and SLCO1B1, whose common variant rs4149056 weakens the transporter that carries it into the liver. Higher levels are linked to a higher chance of statin muscle symptoms. CPIC has published a guideline on both genes and fluvastatin. Studies have also looked at genes linked to how much cholesterol falls, with weaker evidence.
Clinical guidelines that name a gene for Fluvastatin. They sort people into groups by the gene copies they carry.
Every published finding on gene variants and Fluvastatin. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
CYP2C9 CYP2C9*1, CYP2C9*2, CYP2C9*3: Level 1A · replicated. Metabolism/PK. 5.
SLCO1B1 SLCO1B1*1, SLCO1B1*5, SLCO1B1*15: Level 1A · replicated. Metabolism/PK. 4.
SLCO1B1 rs4149056: Level 1A · replicated. Metabolism/PK. 2.
SLCO1B1 rs4149056: Level 1A · replicated. Toxicity: statin-related myopathy. 2.
Studies of how quickly the body processes this medication.
Studies of how well it worked in people carrying a variant.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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