Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Rosuvastatin is a statin: it blocks HMG-CoA reductase, the liver enzyme that makes cholesterol, so the liver takes more LDL cholesterol out of the blood. It is one of the strongest statins and is used to lower cholesterol and to reduce the chance of heart attack and stroke. It is sold as Crestor, among other names.
Rosuvastatin is barely broken down by liver enzymes; what decides its blood level is mainly transport. SLCO1B1 carries it into the liver, and ABCG2 pumps it out of gut and liver cells. Common weaker versions of either (rs4149056 in SLCO1B1, rs2231142 in ABCG2, the latter most frequent in East Asian populations) raise blood levels. CPIC has published a guideline on both genes and rosuvastatin, DPWG on SLCO1B1, and the US FDA lists an effect on drug levels. Other genes linked to how much cholesterol falls have been studied, with weaker evidence.
Clinical guidelines that name a gene for Rosuvastatin. They sort people into groups by the gene copies they carry.
Every published finding on gene variants and Rosuvastatin. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
SLCO1B1 SLCO1B1*1, SLCO1B1*5, SLCO1B1*9, SLCO1B1*14, SLCO1B1*15, SLCO1B1*37: Level 1A · replicated. Metabolism/PK. 14.
SLCO1B1 rs4149056: Level 1A · replicated. Metabolism/PK: Hypercholesterolemia. 13.
ABCG2 rs2231142: Level 1A · replicated. Metabolism/PK. 11.
SLCO1B1 rs4149056: Level 1A · replicated. Toxicity: statin-related myopathy. 8.
Studies of how quickly the body processes this medication.
Studies of how well it worked in people carrying a variant.
Studies of how much of the drug people needed or tolerated.
Studies that do not fall into the groups above.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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