Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Fesoterodine is an antimuscarinic medicine for overactive bladder: it blocks muscarinic receptors in the bladder wall, so the bladder contracts less urgently. It is used for urgency, frequent urination and leakage, and in children for bladder problems caused by nerve damage. It is sold as Toviaz.
Fesoterodine is a prodrug that blood esterases turn into 5-hydroxymethyl tolterodine, the same active form tolterodine makes; that form is then broken down by CYP2D6 and CYP3A4. CYP2D6 poor metabolizers have about twice the exposure, which the US FDA lists as an effect on drug levels. Because the activation does not need CYP2D6, the effect is smaller than for tolterodine. There is no CPIC or DPWG guideline.
Clinical guidelines that name a gene for Fesoterodine. They sort people into groups by the gene copies they carry.
Every published finding on gene variants and Fesoterodine. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
CYP3A4 CYP3A4*1, CYP3A4*3, CYP3A4*20, CYP3A4*22: Level 3. Metabolism/PK. 1.
Studies of how quickly the body processes this medication.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Advair (Corticosteroid + LABA)
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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