Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Didanosine (ddI) was one of the early HIV medicines, a nucleoside reverse transcriptase inhibitor that stops viral DNA from growing. Because of serious side effects such as pancreatitis, nerve damage and liver problems, it has been withdrawn in most countries and replaced by safer medicines. It was sold as Videx.
Didanosine is broken down partly by purine nucleoside phosphorylase and xanthine oxidase (XDH), and activated inside cells. The few gene studies on it looked at XDH and NT5C2 for side effects such as pancreatitis and nerve damage. The findings come from a few studies, and there is no CPIC or DPWG guideline.
Every published finding on gene variants and Didanosine. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
XDH rs1594160: Level 3. Toxicity: HIV infectious disease. 1.
NT5C2 rs11191561: Level 3. Toxicity: HIV infectious disease. 1.
XDH rs1429376: Level 3. Toxicity: HIV infectious disease. 1.
NT5C2 rs11598702: Level 3. Toxicity: HIV infectious disease. 1.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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