Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Diazepam is a benzodiazepine: it strengthens the calming effect of the messenger GABA at its receptors in the brain. It is used for anxiety, muscle spasms, alcohol withdrawal and to stop prolonged seizures, and before some procedures. It and its active breakdown product last a long time in the body. It is sold as Valium, among other names.
Diazepam is broken down by the liver enzymes CYP2C19 and CYP3A4. People with two low-function CYP2C19 copies (poor metabolizers, more common in East Asian populations) clear diazepam and its active breakdown product desmethyldiazepam more slowly, so the effect lasts longer; the US FDA lists an effect on drug levels. There is no CPIC or DPWG guideline, and the other studies on this page are single findings.
Clinical guidelines that name a gene for Diazepam. They sort people into groups by the gene copies they carry.
Every published finding on gene variants and Diazepam. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
CYP2C19 CYP2C19*1, CYP2C19*2, CYP2C19*3: Level 3. Metabolism/PK. 1.
Studies of how quickly the body processes this medication.
Studies of how well it worked in people carrying a variant.
Studies of how much of the drug people needed or tolerated.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Benzodiazepines (class) (Benzodiazepines)
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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