Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Cavosonstat (N91115) was an experimental medicine for cystic fibrosis that inhibits S-nitrosoglutathione reductase, an enzyme thought to help break down the faulty CFTR protein. It was tested alongside ivacaftor and lumacaftor in people with the F508del variant, but did not show enough benefit and was not developed further.
Cavosonstat was meant for cystic fibrosis caused by the F508del variant in CFTR, the gene behind the condition. The gene studies on it come from its clinical trials in people with F508del. There is no CPIC or DPWG guideline.
Every published finding on gene variants and Cavosonstat. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
CFTR rs113993960: Level 3. Efficacy: Cystic Fibrosis. 1.
Studies of how well it worked in people carrying a variant.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Advair (Corticosteroid + LABA)
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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