Your result, the DNA positions behind it, and what the research says.
6/10 confidence.
Creatine kinase leaks slowly out of muscle into blood as a matter of routine, and a blood test measures how much is there. The reference range printed beside that number is drawn from a population, and people differ in where their own resting level sits. Two separate genes shift it: titin, the enormous spring-like protein that gives muscle its passive elasticity, and anoctamin 5, a membrane protein involved in repairing muscle fibers. Hard exercise moves the same number for days, quite separately from either.
Good to know: Creatine kinase leaks from muscle routinely; the test measures the resting level. The printed reference range is a population range, and resting levels differ between people. Hard exercise raises the same enzyme for days, quite apart from genetics.
Fun fact: Titin is the largest protein in the human body, and its full chemical name takes over three hours to say out loud.
Discovery: Common titin variants were linked to resting creatine kinase levels in large population studies of blood biochemistry.
The 2 positions this trait reads
Gene: TTN, ANO5
rs12463674 Titin - raises resting creatine kinase
rs7481951 Anoctamin 5 - raises resting creatine kinase
Location: Chr 2:178,567,458
dbSNP rs12463674
Content updated September 2026.
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