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Type V collagen does not make up much of a tendon by mass, but it controls how the far more abundant type I collagen assembles: it regulates how thick the resulting fibrils grow. Type V collagen does not make up much of a tendon by mass, but it controls how the far more abundant type I collagen assembles: it starts new fibrils and limits how wide they grow. Where there is less of it, fewer fibrils form and the ones that do grow thicker. This variant sits in the untranslated tail of the gene, a region that influences how long the message survives, and it has been associated with measured range of motion in several studies.
Good to know: Type V collagen controls how thick the main collagen fibrils grow. Stiffer tissue returns energy better; suppler tissue gives more range. Habitual stretching moves measured flexibility far more than this variant.
Fun fact: Tendon behaves like a spring during running, storing and returning a large share of the energy of each stride rather than muscle supplying it all.
Discovery: COL5A1 variants were first associated with measured range of motion in 2009.
The single variant behind this trait
Gene: COL5A1
Location: Chr 9:134,842,570
dbSNP rs12722
Content updated September 2026.
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