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Lactate Clearance

Your result, the one DNA position behind it, and what the research says.

4/10 confidence.

About Lactate Clearance

Hard effort makes muscle produce lactate faster than it is used, and a pair of transporters moves it between fibers: one carries it out of the fast-twitch fibers making it, and MCT1, the one this card reads, carries it into the slow-twitch fibers and the heart that burn it as fuel. This card reads a single letter change in that transporter which swaps one amino acid for another and appears to alter how briskly the shuttle works. It is read as a trait about recovery between hard efforts rather than about top speed, and the evidence behind it is thin: the studies are small, and researchers have written this position two different ways in print, which has caused genuine confusion about which version is which.

Good to know: The evidence here is thin and the studies are small, so treat it as a curiosity rather than a finding. Lactate is fuel, not a waste product: it is carried out of muscle and burned elsewhere. Recovery between hard efforts is shaped far more by training and sleep than by this letter.

Fun fact: Lactate was blamed for muscle soreness for most of a century. It is now known to be a fuel the body actively moves around and burns.

Discovery: The amino-acid change in this transporter was described in the early 2000s.

The Variant

The single variant behind this trait

Gene: SLC16A1

Variant (rsID): rs1049434

Location: Chr 1:112,913,924

dbSNP rs1049434

The studies

Muscle Oxygen Saturation Responses During Maximal and Submaximal Exercise According to SLC16A1 (MCT1) Gene Polymorphism in Long-Distance Runners: A Cross-Sectional Pilot Study (Seki S et al., Genes, 2025)

Association Among MCT1 rs1049434 Polymorphism, Athlete Status, and Physiological Parameters in Japanese Long-Distance Runners (Seki S et al., Genes, 2024)

Influence of the MCT1-T1470A polymorphism (rs1049434) on blood lactate accumulation during different circuit weight trainings in men and women (Cupeiro R et al., Journal of science and medicine in sport, 2012)

The polymorphism T1470A of the SLC16A1 gene is associated with the lactate and ventilatory thresholds but not with fat oxidation capacity in young men (Chávez-Guevara IA et al., European journal of applied physiology, 2024)

Other lifestyle traits

Training Response: A change in the gene for the signal that grows new blood vessels, looked at for how people adapt to different kinds of training.

Thigh Muscle Volume: A change in the calcium channel that triggers muscle contraction, linked to measured thigh muscle volume.

Physical Activity: A change on chromosome 17 linked to how much physical activity people report doing.

Back to All Traits

Content updated September 2026.

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