Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Vindesine is a semi-synthetic vinca alkaloid derived from vinblastine. It blocks the assembly of microtubules, so dividing cells cannot separate their chromosomes. It has been used in Europe and Japan for some leukaemias, lymphomas and lung cancer, and is not marketed in the US. It was sold as Eldisine.
Vindesine is broken down mainly by CYP3A4 and pumped out of cells by ABCB1. The gene study listed looked at ABCB1 for side effects. The evidence is weak, and there is no CPIC or DPWG guideline.
Every published finding on gene variants and Vindesine. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
ABCB1 rs2229109: Level 3. Toxicity: Non-Hodgkin Lymphoma. 1.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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