Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Velpatasvir is a hepatitis C NS5A inhibitor that works against all genotypes. Combined with sofosbuvir in one daily tablet (Epclusa), or with sofosbuvir and voxilaprevir (Vosevi), it cures most hepatitis C infections in 12 weeks.
Velpatasvir is excreted mostly unchanged in bile, with a small part broken down by CYP2B6, CYP2C8 and CYP3A4. The gene study listed looked at the IFNL3/IFNL4 region, which mattered much more for older interferon treatment; with velpatasvir combinations its effect on cure is small. There is no CPIC or DPWG guideline.
Every published finding on gene variants and Velpatasvir. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
IFNL3;IFNL4 rs12979860: Level 3. Efficacy: Chronic hepatitis C virus infection. 1.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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