Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Daclatasvir is a direct-acting antiviral for hepatitis C that blocks NS5A, a viral protein needed for copying the virus and assembling new particles. Combined with sofosbuvir, it cured most hepatitis C infections across genotypes, and remains on the WHO essential medicines list, though in richer countries newer combinations have replaced it. It was sold as Daklinza.
Daclatasvir is broken down mainly by CYP3A4. The gene studies listed looked at the IFNL3 (IL28B) region, which mattered much more for interferon-based treatment, and at genes such as HINT1 and NME1 involved in activating sofosbuvir, given with it. The findings come from a few studies, and there is no CPIC or DPWG guideline.
Every published finding on gene variants and Daclatasvir. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
IFNL3;IFNL4 rs12979860: Level 3. Efficacy: Chronic hepatitis C virus infection. 1.
Studies of how quickly the body processes this medication.
Studies of how well it worked in people carrying a variant.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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