Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
VEGF and VEGFR inhibitors block the signal blood vessels use to grow. In cancer, antibodies such as bevacizumab and ramucirumab and tablets such as sunitinib, axitinib and lenvatinib cut off tumours' blood supply; in the eye, injections of ranibizumab, aflibercept, faricimab and bevacizumab stop leaky new vessels in wet macular degeneration and diabetic eye disease. This page collects studies on the group as a whole.
The gene studies listed for the group looked at VEGFA and TRIB1 for response. Gene findings for individual medicines are on their own pages: VEGF pathway genes for the cancer medicines, and CFH, ARMS2 and VEGFA for the eye injections. The findings come from a few studies, and there is no CPIC or DPWG guideline.
Every published finding on gene variants and Anti-VEGF Agents. Upload your DNA file to see which of these rows apply to you.
Studies of how well it worked in people carrying a variant.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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