Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Bevacizumab is a biologic medicine, a monoclonal antibody that neutralises VEGF, the signal tumours use to grow new blood vessels. Given by drip, it is used with chemotherapy for bowel, lung, ovarian, cervical, kidney and brain cancers; as an injection into the eye, it is used off label for wet age-related macular degeneration. It is sold as Avastin and as biosimilars.
As an antibody, bevacizumab is not broken down by drug-processing enzymes. Studies in cancer have looked at variants in VEGFA and its pathway (EPAS1, ANGPT2) for how well it worked. Studies in macular degeneration have looked at CFH and ARMS2, genes linked to that eye condition, for response to eye injections. The findings come from single or a few studies, and there is no CPIC or DPWG guideline.
Every published finding on gene variants and Bevacizumab. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
MTHFR rs1801131: Level 3. Efficacy: Neoplasms. 4.
VEGFA rs3025039: Level 3. Efficacy: Breast Neoplasms, Colorectal Neoplasms. 3.
ARMS2 rs10490924: Level 3. Efficacy: Macular Degeneration. 2.
VEGFA rs699947: Level 3. Efficacy: Colorectal Neoplasms. 2.
Studies of how well it worked in people carrying a variant.
Studies of how much of the drug people needed or tolerated.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Anti-VEGF Agents (class) (Anti-VEGF Agents)
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
ReadYourDNA provides educational interpretation of DNA data you already have. It is not diagnostic, not a substitute for professional medical advice, diagnosis, or treatment, and is not intended to diagnose, treat, cure, or prevent any disease. Talk to a clinician before acting on any result.
Raw DNA Data Reports for 23andMe & AncestryDNA · About ReadYourDNA · FAQ · Methodology & Science · Pricing · Support and complaints · Legal & Contact · Health Traits · Pharmacogenomics · Carrier Status · Variant Explorer · The Human Karyotype · Privacy Policy · Terms of Service · Accessibility · Consumer Health Data Privacy · Your Privacy Choices · Editorial Standards · Your Data, Checkable · Sample Report · ReadYourDNA and Promethease compared · What is inside a 23andMe raw data file · What is inside an AncestryDNA raw data file · What a chatbot can and cannot do with your raw DNA file · Where a raw DNA file can still be uploaded in 2026
Written, maintained and operated by Martin Pechhacker, sole proprietor, Vienna, Austria. Trade register GISA 40064420. support@readyourdna.com