Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Ticlopidine was the first thienopyridine antiplatelet medicine, an older relative of clopidogrel that blocks the P2Y12 receptor on platelets. It was used to prevent strokes and to keep stents open, but because of rare serious blood disorders it has been replaced by clopidogrel and newer medicines and is withdrawn in many countries. It was sold as Ticlid.
Like clopidogrel, ticlopidine is a prodrug activated by liver enzymes, including CYP2C19 and CYP2B6, and a few studies looked at CYP2C19 for its effect. Others linked HLA-A*33:03 and related HLA-B and HLA-C types, mainly in Japanese patients, to ticlopidine-induced liver injury. The findings come from a few studies, and there is no CPIC or DPWG guideline.
Every published finding on gene variants and Ticlopidine. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
HLA-B HLA-B*44:03: Level 3. Toxicity. 1.
HLA-C HLA-C*14:03: Level 3. Toxicity: Toxic liver disease. 1.
Studies of how well it worked in people carrying a variant.
CYP2C19 rs4244285: Genotype AA is not associated with response to ticlopidine.
CYP2C19 rs4986893: Genotype AA is not associated with response to ticlopidine.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Brilinta (Antiplatelet Agents)
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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