Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Prasugrel is an antiplatelet medicine of the thienopyridine family, like clopidogrel: it permanently blocks the P2Y12 receptor on platelets so they are less likely to clump. It is used with aspirin in people with acute coronary syndrome who are treated with a stent. It is sold as Effient and Efient.
Prasugrel is also a prodrug, but it is activated in a single step mainly by CYP3A4 and CYP2B6, so CYP2C19 variants hardly affect it. That is why clinical guidelines name it, with ticagrelor, as an alternative for people whose CYP2C19 genes make clopidogrel less effective. Studies on prasugrel itself confirmed that CYP2C19 has little effect and looked at the platelet gene PEAR1, with weak evidence. There is no CPIC or DPWG guideline for prasugrel itself.
Every published finding on gene variants and Prasugrel. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
NTRK1;PEAR1 rs2768759: Level 3. Efficacy. 3.
CYP2C19 rs4244285: Level 3. Efficacy: Acute coronary syndrome. 2.
PEAR1 rs12407843: Level 3. Efficacy. 1.
PEAR1 rs77235035: Level 3. Efficacy. 1.
Studies of how quickly the body processes this medication.
Studies of how well it worked in people carrying a variant.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Brilinta (Antiplatelet Agents)
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
ReadYourDNA provides educational interpretation of DNA data you already have. It is not diagnostic, not a substitute for professional medical advice, diagnosis, or treatment, and is not intended to diagnose, treat, cure, or prevent any disease. Talk to a clinician before acting on any result.
Raw DNA Data Reports for 23andMe & AncestryDNA · About ReadYourDNA · FAQ · Methodology & Science · Pricing · Support and complaints · Legal & Contact · Health Traits · Pharmacogenomics · Carrier Status · Variant Explorer · The Human Karyotype · Privacy Policy · Terms of Service · Accessibility · Consumer Health Data Privacy · Your Privacy Choices · Editorial Standards · Your Data, Checkable · Sample Report · ReadYourDNA and Promethease compared · What is inside a 23andMe raw data file · What is inside an AncestryDNA raw data file · What a chatbot can and cannot do with your raw DNA file · Where a raw DNA file can still be uploaded in 2026
Written, maintained and operated by Martin Pechhacker, sole proprietor, Vienna, Austria. Trade register GISA 40064420. support@readyourdna.com