Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Thiotepa is an alkylating chemotherapy medicine that cross-links DNA. At high doses it is used to prepare the bone marrow before stem cell transplants, especially in children with blood disorders and in some brain tumours; it is also placed directly in the bladder for some bladder cancers. It is sold as Tepadina, among other names.
Thiotepa is converted by CYP2B6 and CYP3A4 into TEPA, also active, and both are inactivated by joining to glutathione with the help of glutathione transferases. The gene studies listed looked at GSTP1 for its clearance and at ALDH1A1 for side effects. The findings come from a few studies, and there is no CPIC or DPWG guideline.
Every published finding on gene variants and Thiotepa. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
GSTP1 rs1138272: Level 3. Metabolism/PK: Neoplasms. 1.
ALDH1A1 rs6151031: Level 3. Toxicity. 1.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Alkylating Agents (class) (Alkylating Agents)
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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